The Neuro Ones · Sensitive type · By Flore

For a sensitive system that reacts to everything.

A multi-strain, single-target formula that leaves out histamine-producing L. reuteri on purpose, with chia, resistant potato starch and a small amount of reishi. It shifts your gut mix toward a system that reacts less and settles more.

  • Multi-strain, one job
  • 24 Billion CFU per capsule
  • One capsule a day, shelf-stable
  • Made in an FDA-registered US facility
Settle30 capsules · 30-day supply · SETTLE
$49single bottle
One bottle, one time. No subscription required.
Try Settle · $49 →

Checkout opens securely on Shopify. Ships in 2–5 business days. Want more than one? Mix any two for $90 or four for $179.

Settle by GoodOnes
Multi-strain. 1 job.Settle down
23,000+microbiome reports analyzed
cGMP facilityFDA-registered, USA
4.5  Flore family · 329 Trustpilot reviews
23,000+  microbiome reports analyzed
18,700+  people served
cGMP  FDA-registered US facility

Why a targeted formula

Histamine doesn’t only come from pollen.

Some gut bacteria make it. Settle is built around the ones it leaves out.

Matched to one pattern

Built for the Sensitive type: probiotic base, prebiotics and one small modulator. No Universal core in this one.

Every ingredient on the label

Genus and species printed on the Supplement Facts panel, with the published research on each strain cited per formula. Look any of them up yourself.

Shelf-stable, no fridge

Shelf-stable through the printed expiry date. Gluten-free, non-GMO, no dairy, no soy. Made in an FDA-registered, cGMP-compliant US facility.

What’s inside

Fewer reactions, by design.

L. plantarum, B. longum, B. bifidum and L. rhamnosus, with no L. reuteri, fed by chia seed and Solnul® resistant potato starch. A small amount of reishi works alongside.

  • Multi-strain, single-target. One job per bottle.
  • 24 Billion CFU per capsule, total.
  • Every ingredient named on the label.
  • No subscription to try it.
Try Settle · $49 →
What’s insideServing size 1 capsule · 30 servings
Phenotype-matched base
Lactiplantibacillus plantarum†
Bifidobacterium longum†
Bifidobacterium bifidum†
Lacticaseibacillus rhamnosus†
Prebiotic
Chia seed (140 mg) + Solnul® resistant potato starch (150 mg)
Modulators · small amounts, chosen to work with the base
ReishiGanoderma lucidum10 mg
Proprietary probiotic blend, 24 Billion CFU total per capsule. †Daily value not established. Strains listed by genus and species; full designations on file with Flore. One capsule a day with food. Two a day is the maximum across any GoodOnes you stack.

From checkout to day 30

What happens after you order

The research is the backbone. What you feel is the point.

Step 1

Checkout on Shopify

Settle is already in the cart. Orders are typically processed within 2–5 business days and ship USPS or UPS Ground. No cold chain needed.

Step 2

One capsule a day

Take it with a meal. One a day is the sweet spot. Stacking a second GoodOne? Two a day is the maximum.

Step 3

Judge it at day 30

Count the reactive days in week four against week one. Individual results vary.

Try Settle · $49 →

30-day supply. No subscription required. Checkout opens securely on Shopify.

How it works

A sensitive system carries a heavier load.

Some gut bacteria produce histamine. In a sensitive system that extra load shows up in more than one place: the gut, the skin, the whole day.

Settle keeps the strains that support a calmer baseline, leaves the histamine producer out, and feeds the rest with chia and resistant potato starch.

Settle or The Calm One?

Similar names, different jobs. The Calm One is for steady focus and calm. Settle is for a system that reacts to everything.

What we will and won’t claim

We will say: The species in Settle have been studied for barrier and reactivity measures in published research. The citations are listed on the Settle product page. Those are studies of the strains, not trials of the finished GoodOnes formula. GoodOnes has not run its own randomized controlled trials of the finished formulas.

We will not say: that it treats any allergic, skin or other condition, or replaces care from a clinician. Settle is structure-function support for one body system. Individual results vary.

Settle bottleSETTLE · Settle

Who makes it

Built by the microbiome scientists at Flore.

GoodOnes is the targeted-formula line from Flore Inc., a microbiome company founded in 2018. The formulas come from what Flore’s microbiome dataset shows, packaged as one job per bottle.

23,000+microbiome reports analyzed
18,700+people served across the Flore family
10 yearsof paired microbiome and outcome data
cGMPFDA-registered US facility. Made in America.

Want a formula built from your own gut data? That’s Flore: a microbiome test, then a formula made from your results.

4.5 out of 5Flore family rating from 329 reviews on TrustpilotRead the reviews →

Is this your One?

The probiotic brand that tells you when not to buy.

A targeted formula only earns its keep if it’s aimed at your actual pattern. Read both columns before you order.

Settle is for you if

  • You feel sensitive to a lot of foods.
  • Your skin reacts when your gut does.
  • Hormonal ups and downs hit your gut hard.
  • You’re 18 or over and want to try one bottle first.

Skip it if

  • You’re pregnant or nursing. Talk to your doctor first.
  • You take blood thinners or blood pressure medication and haven’t asked your doctor. This contains reishi.
  • Only your skin is the issue and it tracks your gut. The Clear One fits better.
  • You want a treatment. This is a dietary supplement. It is not intended to diagnose, treat, cure, or prevent any disease.

Read this before you order.

Contains reishi. If you take blood thinners or blood pressure medication, ask your doctor first.

On a prescription? Keep taking it exactly as prescribed, and show your doctor the label if you’d like their take.

Questions

Before you order

What is the Sensitive type?

One of the gut-brain patterns from the 60-second gut-brain quiz: a system that reacts to foods, on the skin and in the gut.

Why leave out L. reuteri?

It’s a useful species in other Ones, but it can produce histamine. For a sensitive system, leaving it out is the point.

What is Solnul®?

A resistant potato starch. It’s a prebiotic fiber that feeds the base strains.

Do I need a subscription?

No. This page sells one bottle for $49, one time. Want two or four? Mix any Ones for $90 a pair or $179 for four on realgoodones.com. Monthly? Subscribe & Save takes 10% off there, and you can cancel before any renewal by emailing support@flore.com.

What is the shipping and return policy?

Orders are typically processed within 2–5 business days and ship USPS or UPS Ground (5–7 business days), with expedited options priced at checkout. All sales are final except for orders that arrive damaged, defective, or incorrect, which Flore replaces or refunds if you email support@flore.com within 14 days of delivery. Full details on the shipping and returns pages.

Who should not take it?

The adult GoodOnes formulas are for ages 18 and over. They are not appropriate for active GI diagnoses that require medical management. If you are pregnant, nursing, have a weakened immune system, or take prescription medication, talk to your doctor before adding any probiotic.

Ready when you are

One bottle. Thirty days. Let things settle.

No test, no stool sample, no subscription. One targeted formula for the Sensitive pattern, every ingredient on the label. If it isn’t your One, the Flore team will say so.

Try Settle · $49 →

30-day supply. Checkout opens securely on Shopify. Ships in 2–5 business days.

Settle by GoodOnes One capsule a day Built for Sensitive No subscription Made in the USA

Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Individual results vary. Settle is a general-wellness dietary supplement formulated for adults 18 and over. Strain selection is informed by Flore’s dataset of microbiome reports and by published research on the individual strains; where we describe strain research, we mean published studies on the individual strains, not trials of the finished GoodOnes formula. Consult your healthcare provider before starting any supplement, particularly if you are pregnant, nursing, have a medical condition, or take prescription medication.